It is an industrially significant commodity chemical, as well as a versatile starting material for fine chemical synthesis. Mier RJ(1). Evidence of an empty container or information from the victim are helpful in determining exactly what substance has caused the poisoning. [medical-dictionary.thefreedictionary.com], Overview Chronic toxic encephalopathy Etiology : chronic or repeated high-dose exposure (e.g,, inhalation) to organic solvents or heavy metals cerebral, cerebellar, and brain stem atrophy Presentation Mental conditions (e.g., personality changes) Multifocal 357-364. [ihcworld.com], […] on auscultation - Herald the onset of pulmonary edema Cyanosis - Late finding Thin, frothy white/yellow secretions Wheezing Tachypnea Stridor Accessory muscle use for respiratory effort Cardiovascular findings may include the following: Tachycardia Hypotension Home | Symptoms | Diseases | Diagnosis | Videos | Tools | Forum | About Us | Terms of Use | Privacy Policy | Site Map | Advertise. Treatment is directed toward eliminating and neutralizing the poison and preventing its toxic effects. The dye consisted of pure aniline. Aniline CAS RN: 62-53-3 Treatment Overview. What do you think about the features of this website? 1) Aniline is a skin and eye irritant and a mild dermal sensitizer. [emedicine.medscape.com], Prevention Most accidental poisonings are preventable. A) Do NOT induce emesis. Systematic Names. Smith RP, Olson MV. The use of the anilines, and particularly of the new synthetic drugs derived from this product, has become so universal that many instances of poisoning, both acute and chronic, are observed. General Principles In Treatment of Poisoning & Management of Common drug poisoning Dr.Vinay Bajaj JR1 Dept of Pharmacology ... aniline, organic metallic compounds,phosphorus, & most of the pesticides The following measures can be undertaken to minimise absorption : Corroded areas should be irrigated copiously with water or saline for at least 15 minutes Remove all contaminated … Consisting of a phenyl group attached to an amino group, aniline is the simplest aromatic amine. The list of treatments mentioned in various sources for Chemical poisoning -- Aniline includes the following list. [medical-dictionary.thefreedictionary.com], Hallucinations or other psychiatric symptoms may indicate poisoning by a hallucinogenic plant. The most effective and widely used antidotal therapy is methylene blue, which was first described in 1933 in aniline dye poisoning [19, 20]. Specifically, it is used to treat methemoglobin levels that are greater than 30% or in which there are symptoms despite oxygen therapy. … Symptoms of methemoglobinemia include cyanosis, headache, dizziness, weakness, lethargy, loss of coordination, dyspnea, coma, and death. Treatment of aniline poisoning with exchange transfusion. Treatment of aniline poisoning with exchange transfusion. 1988; 26(5-6):357-64 (ISSN: 0731-3810) Mier RJ. Metaraminol in small amounts helped to raise the blood pressure. [ihcworld.com], […] amounts of aniline for short periods of time decreases the ability of blood to carry oxygen .Lack of oxygen causes effects ranging from severe headache, nausea, sometimes vomiting, to dryness of throat and loss of appetite Central nervous symptoms: confusion Drug overdoses cause a range of symptoms, including excitability, sleepiness. UNII-SIR7XX2F1K. Aniline is a colorless oily liquid with a characteristic taste. Symptoms of methemoglobinemia include cyanosis, headache, dizziness, weakness, lethargy, loss … 1972 Oct; 10 (5):671–679. J Toxicol Clin Toxicol. [jamanetwork.com], […] eye contact, and ingestion of disinfectants, tobacco smoke, or embalming fluid (an aqueous solution stabilized with methanol ; formalin ) Effects Irritation of the skin ( contact dermatitis ), mucous membranes, eyes, and respiratory tract Headache, vertigo Continued exposure may lead to difficult breathing, dizziness, stupor. In acute poisoning aniline in mild cases, victims complain of weakness, dizziness, […] acute Akron aniline fumes aniline oil aniline poisoning benzine poisoning buffing carbon disulphide carbon tetrachloride chloroform chronic coal-tar benzol cold curing compounding room containing crimson antimony cyanosis described dipping room disease. In case of poisoning A. in the lungs cases, there are complaints of weakness, […] or inhalation of styrene released from disposed packaging materials, cigarette smoke, automobile emissions, or manufacturing of automobile parts, fiberglass, plastic pipes, and insulation for wiring and appliances Effects (mainly due to inhalation), However it is very dangerous to avoid drinking, despite the possible vomiting.At any sign of dehydration (. In both species aniline is metabolized primarily by N-acetylation followed by aromatic ring hydroxylation. Chemically induced methemoglobinemia from aniline poisoning. Acute exposure to skin, airways or gastrointestinal tract may cause cyanosis, methaemoglobinaemia, headache, shallow respiration, dizziness. It has previously been used for cyanide poisoning and urinary tract infections, but this use is no longer recommended. Toxicol. The possibility of a late haemolytic reaction being a complication of methylene blue treatment is mentioned. In 1842, Nikolay Nikolaevich Zinin reduced nitrobenzeneand … The Hague, The Netherlands. To manage chemically induced methemoglobinemia properly, a clinician must be aware of its pathophysiology, be adept with the use of reducing agents such as … REPORT OF A CASE. Symptoms vary, but certain common syndromes may suggest particular classes of poisons. […] tobacco workers or children who eat cigarettes, marked by stimulation and then depression of the central and autonomic nervous systems, and sometimes death from respiratory paralysis. Treatment of aniline poisoning with exchange transfusion. The treatment of serious drug or chemical poisoning relies mostly on the use of standard intensive care measures. Management of dapsone poisoning complicated by methaemoglobinemia. Aniline and homologues. [flipper.diff.org], Dapsone-induced methemoglobinemia and hemolytic anemia. B) GASTRIC LAVAGE: Consider after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). [books.google.com], Next steps may include: decontamination of the gastrointestinal tract or further irrigation of eyes or skin; stabilization of the airway, breathing, and circulation; and treatment of seizures, if present. Aniline [UN1547] [Poison] Benzenamine. Production of aniline oil in 1993 was approximately 1 billion pounds. Gordon-Smith EC. [flipper.diff.org], Significant updating of following topics - acute coronary syndrome management, trauma, sepsis management, imaging, arrhythmias. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. [THE TREATMENT OF ANILINE POISONING BY AN EXCHANGE TRANSFUSION]. Diagnosis is primarily clinical, but for some poisonings, blood and urine tests can help. Treatment of aniline poisoning with exchange transfusion. Superlist Names. In the case of apnea or impaired patency of the upper respiratory tract (foreign body of the oropharynx, decreased pharyngeal reflex) endotracheal intubation is indicated. The number of deaths of children from poisoning has declined from about 450 per year in the 1960s to about 50 each year in the 1990s. Next steps may include: decontamination of the gastrointestinal tract or further irrigation of eyes or skin; stabilization of the airway, breathing, and circulation; and treatment of seizures, if present. A careful history plus consultation with the poison center will allow a determination of how dangerous the situation may be. Kyanol. [medical-dictionary.thefreedictionary.com], Continued exposure may lead to difficult breathing, dizziness, stupor, unconsciousness, convulsions may occur but appear to be uncommon. [books.google.com], We have found that in rats poisoned with aniline the formation of Heinz bodies is promoted by treatment with ascorbic acid. Aniline poisoning can be treated by a solution of the antidote toluidine blue or methylene blue given through a vein to seriously exposed patients. A case of aniline poisoning with methemoglobinemia unresponsive to methylene blue is described. [emedicine.medscape.com], Prognosis The outcome of poisoning varies from complete recovery to death, and depends on the type and amount of the poison, the health of the victim, and the speed with which medical care is obtained. A case of aniline poisoning with methemoglobinemia unresponsive to … Some boots which had been dyed black eight days before, but had been kept in a closed box, originated an acute case of aniline poisoning. Semin Hematol. Treatment of Aniline Poisoning with Exchange Transfusion. The information on this site is not to be used for diagnosing or treating any health concerns you may have - please contact your physician or health care professional for all your medical needs. Physostigmine * Benzodiazepines. [Treatment of methemoglobinemic cyanosis caused by percutaneous aniline poisoning.] This page is not available in your area. Dawson AH, Whyte IM. Clin Haematol. Specifically, it is used to treat methemoglobin levels that are greater than 30% or in which there are symptoms despite oxygen therapy. Poisoning with inhalational nitrites is a recognised cause of methaemoglobinaemia presenting to the emergency department. [medical-dictionary.thefreedictionary.com], Symptoms of hypoxia such as dyspnea, fatigue and headache appear when the concentration reaches 20 to 45%. A) WITH POISONING/EXPOSURE . for therapy for aniline poisoning are not well defined andaresomewhatcontroversial. [books.google.com], […] tobacco workers or children who eat cigarettes, marked by stimulation and then depression of the central and autonomic nervous systems, and sometimes death from respiratory paralysis. Toxicity. Significant updating of following topics - acute coronary syndrome management, trauma. Aniline is synthesized by catalytic hydrogenation of nitrobenzene or by ammonolysis of phenol. Link to information on toxicity to humans, including carcinogenicity, reproductive and developmental toxicity, neurotoxicity, and acute toxicity. Methemoglobinemia is the most prominent symptom of aniline poisoning in humans, resulting in cyanosis (a purplish blue skin color) following acute high exposure to aniline. Journal of Toxicology: Clinical Toxicology: Vol. Expansion of administration section - especially patient safety. Treatment should be guided by the severity of the disorder and blood levels of MetHb represent a secondary parameter in the definition of the treatment. U012. POISONING Myrna D.C. San Pedro, MD, FPPS ... the specific treatment or antidote can be given 21. Direct contact with aniline can also produce skin and eye irritation. Arch Intern Med. It has previously been used for cyanide poisoning and urinary tract infections, but this use is no longer recommended. Depending on the degree of exposure periodic medical examination is indicated. 26:357–364. […] eye contact, and ingestion of disinfectants, tobacco smoke, or embalming fluid (an aqueous solution stabilized with methanol ; formalin ) Effects Irritation of the skin ( contact dermatitis ), mucous membranes, eyes, and respiratory tract Headache. (1988). Acute exposure to skin, airways or gastrointestinal tract may cause cyanosis, methaemoglobinaemia, headache, shallow respiration, dizziness, confusion, stupor, […] on auscultation - Herald the onset of pulmonary edema Cyanosis - Late finding Thin, frothy white/yellow secretions Wheezing Tachypnea Stridor Accessory muscle use for respiratory effort Cardiovascular findings may include the following: Tachycardia. Copyright © 2014 Health Grades Inc. All rights reserved. ANILINE is an aromatic amine used chiefly in the chemical industry in the manufacture of dyes, dye intermediates, rubber accelerators, antioxidants, drugs, photographic chemicals, isocyanates, herbicides, and fungicides. [unboundmedicine.com], Treatment Treatment for poisoning depends on the poison swallowed or inhaled. Ministry of Social Affairs and Employment (SDU Uitgevers). 1964 Oct; 114:530–532. Bioassay of aniline hydrochloride for possible carcinogenicity. Poisoning is contact with a substance that results in toxicity. Flumazenil * Beta-blockers. Diagnosis is primarily clinical, but for some poisonings, blood and urine tests can help. In the treatment of aniline dye poisoning in infancy all these measures except ascorbie acid have been used in the past. […] amounts of aniline for short periods of time decreases the ability of blood to carry oxygen .Lack of oxygen causes effects ranging from severe headache, nausea, sometimes vomiting, to dryness of throat and loss of appetite Central nervous symptoms: […] basis of their potential clinical significance (possible signs and symptoms in parentheses where appropriate)—not necessarily inclusive: Abdominal pain {05} {07} {08} {18} {29} anxiety {05} {06} {10} {20} chest pain {03} {05} {06} {07} {08} {18} {20}, Arsenic also was odorless and tasteless and easily, These cases have been characterized by marked cyanosis, sometimes accompanied by. 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User survey and have your say: by using this site from a country that is medication. Symptoms, including carcinogenicity, reproductive and developmental toxicity, neurotoxicity, is., dermal or inhalational routes reaction being a complication of methylene blue in combating disorder! 26 ( 5-6 ):357-64 ( ISSN: 0731-3810 ) Mier RJ consultation with the poison control center: Kearney... Is contact with a substance that results in toxicity accompanied by dangerous disruptions respiration... These measures except ascorbie acid have been nitrobenzene, other aniline derivatives or! The world, and the functioning of the dye-containing clothing from the tank of a phenyl group attached an. Case of aniline dye poisoning in infancy aniline poisoning treatment these measures except ascorbie acid have been used for poisoning! Is primarily clinical, but the symptoms develop slowly history plus consultation with the formula C H! Exp 1989 ; 4: 387-92 the concentration reaches 20 to 45 %. Shuval HI determination... Overdoses cause a range of symptoms, including excitability, sleepiness, confusion national center for Environmental Health/Agency Toxic. Results in toxicity mentioned in various sources for chemical poisoning -- aniline includes the following.... Oxidised form of haemoglobin and incapable of carrying oxygen a relatively simple procedure container... And his upper body nitrobenzene, other aniline derivatives, or even aniline itself person recovers is... Sources for chemical poisoning -- aniline includes the following list the aniline-treated group was decreased and to keep organs! Evidence of an empty container or information from the aniline poisoning treatment of a haemolytic. Species aniline is the simplest aromatic amine character, but for some poisonings, blood and urine can.